Início  /   Expression of a LINE-1 endonuclease variant in gastric cancer: its association with clinicopathological parameters

Expression of a LINE-1 endonuclease variant in gastric cancer: its association with clinicopathological parameters


Long interspersed nuclear element-1 (LINE-1 or L1), the most abundant and only autonomously active family of non-LTR retrotransposons in the human genome, expressed not only in the germ lines but also in somatic tissues. It contributes to genetic instability, aging, and age-related diseases, such as cancer. Our previous study identified in human gastric adenocarcinoma an upregulated transcript GCRG213, which shared 88% homology with human LI sequence and contained a putative conserved apurinic/apyrimidinic endonucleas1 domain.