Início  /   Characteristic mTOR activity in Hodgkinlymphomas offers a potential therapeutic target in high risk disease – a combined tissue microarray, in vitro and in vivo study

Characteristic mTOR activity in Hodgkinlymphomas offers a potential therapeutic target in high risk disease – a combined tissue microarray, in vitro and in vivo study


Targeting signaling pathways is an attractive approach in many malignancies. The PI3K/Akt/mTOR pathway is activated in a number of human neoplasms, accompanied by lower overall and/or disease free survival. mTOR kinase inhibitors have been introduced in the therapy of renal cell carcinoma and mantle cell lymphoma, and several trials are currently underway. However, the pathological characterization of mTOR activity in lymphomas is still incomplete.